TocilizumabV1, 2020, Analysis, bibRecord, 000257

New insights into the treatment of myositis

Identifieur interne : 000257 ( 2020/Analysis ); précédent : 000256; suivant : 000258

New insights into the treatment of myositis

Auteurs : Stefanie Glaubitz ; Rachel Zeng ; Jens Schmidt

Source :

Therapeutic Advances in Musculoskeletal Disease [ 1759-720X ] ; 2020.

RBID : PMC:6950531

Abstract

The myositis syndromes include polymyositis, dermatomyositis (DM), necrotizing myopathy, inclusion body myositis (IBM), antisynthetase syndrome and overlap syndromes with myositis. These syndromes mostly occur in middle-aged patients, while juvenile DM occurs in children and adolescents. Patients mostly show a subacute weakness and myalgia in the upper and lower limbs, the diagnosis is based upon these clinical findings in combination with muscle biopsy results and specific serum autoantibodies. In recent years, research achieved a better understanding about the molecular mechanism underlying the myositis syndromes, as well as disease progress and extramuscular organ manifestations, such as interstitial lung disease and association with neoplasias. Treatment mainly consists of glucocorticosteroids and immunosuppressants. IBM is usually refractory to treatments. This review provides an overview of the current standards of treatment and new treatment options like monoclonal antibodies and new molecular therapies and their first results from clinical trials.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950531

DOI: 10.1177/1759720X19886494
PubMed: 31949477
PubMed Central: 6950531

Affiliations:

Links to Exploration step

PMC:6950531

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>The myositis syndromes include polymyositis, dermatomyositis (DM), necrotizing myopathy, inclusion body myositis (IBM), antisynthetase syndrome and overlap syndromes with myositis. These syndromes mostly occur in middle-aged patients, while juvenile DM occurs in children and adolescents. Patients mostly show a subacute weakness and myalgia in the upper and lower limbs, the diagnosis is based upon these clinical findings in combination with muscle biopsy results and specific serum autoantibodies. In recent years, research achieved a better understanding about the molecular mechanism underlying the myositis syndromes, as well as disease progress and extramuscular organ manifestations, such as interstitial lung disease and association with neoplasias. Treatment mainly consists of glucocorticosteroids and immunosuppressants. IBM is usually refractory to treatments. This review provides an overview of the current standards of treatment and new treatment options like monoclonal antibodies and new molecular therapies and their first results from clinical trials.</p>
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   |wiki=    Sante
   |area=    TocilizumabV1
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   |étape=   Analysis
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   |clé=     PMC:6950531
   |texte=   New insights into the treatment of myositis
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New insights into the treatment of myositis

New insights into the treatment of myositis

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